Abstract\nBackground: Regional anesthesia could affect the homeostatic system functions resulting frequently in\nperioperative hypothermia and consequently shivering. The objective of this trial was to evaluate the efficacy of\ndexmedetomidine and ondansetron to reduce the incidence and severity of shivering after intrathecal blocks.\nMethods: This randomized placebo-controlled trial included 120 patients allocated equally in three groups. All\npatients were anesthetized by standard intrathecal blocks for surgical procedure at lower half of the body and\nreceived one of the study drugs intravenously (IV) according to the group assignments. Group S patients (placebo)\nwere administered saline, Group O (ondansetron) were given 8 mg ondansetron, and Group D (dexmedetomidine)\nwere given 1 ----g/kg of dexmedetomidine. Shivering incidence and scores, sedation scores, core body temperature,\nhemodynamic variables, and incidence of complications (nausea, vomiting, hypotension, bradycardia, over-sedation,\nand desaturation) were recorded.\nResults: The incidence and 95 confidence interval (95% CI) of shivering in group S 57.5% (42.18â??72.82%) was\nsignificantly higher than that of both group O 17.5% (5.73â??29.27%), P < 0.001 and group D 27.5% (13.66â??41.34%),\nP = 0.012. However, the difference in the incidence of shivering between group O and group D was comparable,\nP = 0.425. The sedation scores were significantly higher in group D than those of both group S and group O, P < 0.\n001. Sedation scores between group S and group O were comparable, P = 0.19. Incidences of adverse effects were\ncomparable between the three groups.\nConclusion: Prophylactic administrations of dexmedetomidine or ondansetron efficiently decrease the incidence\nand severity of shivering after spinal anesthesia as compared to placebo without significant difference between\ntheir efficacies when compared to each other.\nTrial registration: Pan African Clinical Trial Registry (PACTR) under trial number (PACTR201710002706318). 18-10-2017.\nâ??retrospectively registeredâ??.
Loading....